Day: June 29, 2020

A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys

Not only did the system work in 13 monkeys, the researchers reported, but it appeared that every liver cell was edited. After gene editing, the monkeys’ LDL levels dropped by 59 percent within two weeks. The ANGPTL3 gene editing led to a 64 percent decline in triglyceride levels.

One danger of gene editing is the process may result in modification of DNA that scientists are not expecting. “You will never be able to have no off-target effects,” warned Dr. Deepak Srivastava, president of the Gladstone Institutes in San Francisco.

In treating a condition as common as heart disease, he added, even an uncommon side effect can mean many patients are affected. So far, however, the researchers say that they have not seen any inadvertent editing of other genes.

Another question is how long the effect on cholesterol and triglyceride levels will last, Dr. Davidson said. “We hope it will be

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Actual Coronavirus Infections Vastly Undercounted, C.D.C. Data Shows

The number of coronavirus infections in many parts of the United States is more than 10 times higher than the reported rate, according to data released on Friday by the Centers for Disease Control and Prevention.

The analysis is part of a wide-ranging set of surveys started by the C.D.C. to estimate how widely the virus has spread. Similar studies, sponsored by universities, national governments and the World Health Organization, are continuing all over the world.

The C.D.C. study found, for instance, that in South Florida, just under 2 percent of the population had been exposed to the virus as of April 10, but the proportion is likely to be higher now given the surge of infections in the state. The prevalence was highest in New York City at nearly 7 percent as of April 1.

“This study underscores that there are probably a lot of people infected

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