Disease

A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys

Not only did the system work in 13 monkeys, the researchers reported, but it appeared that every liver cell was edited. After gene editing, the monkeys’ LDL levels dropped by 59 percent within two weeks. The ANGPTL3 gene editing led to a 64 percent decline in triglyceride levels.

One danger of gene editing is the process may result in modification of DNA that scientists are not expecting. “You will never be able to have no off-target effects,” warned Dr. Deepak Srivastava, president of the Gladstone Institutes in San Francisco.

In treating a condition as common as heart disease, he added, even an uncommon side effect can mean many patients are affected. So far, however, the researchers say that they have not seen any inadvertent editing of other genes.

Another question is how long the effect on cholesterol and triglyceride levels will last, Dr. Davidson said. “We hope it will be

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Obesity Linked to Severe Coronavirus Disease, Especially for Younger Patients

Another NYU Langone study, which focused on patients under the age of 60, found that those with obesity were twice as likely to be hospitalized and were at even higher risk of requiring critical care. The association between obesity and more severe disease was not seen in patients over the age of 60.

The severity of the illness often comes as a surprise to younger adults, and “provides another layer of shock to this disease,” the paper’s author, Dr. Jennifer Lighter, said.

Studies highlighting the risks of obesity have been conducted in other countries as well.

Though most of the early reports from China pointed to risk factors like Type 2 diabetes and hypertension, which are common in people with obesity, scientists in Shenzhen, China, reported in The Lancet this month that Covid-19 patients with a high body mass index were at more than double the risk of severe

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