Monkeys

A ‘Cure for Heart Disease’? A Single Shot Succeeds in Monkeys

Not only did the system work in 13 monkeys, the researchers reported, but it appeared that every liver cell was edited. After gene editing, the monkeys’ LDL levels dropped by 59 percent within two weeks. The ANGPTL3 gene editing led to a 64 percent decline in triglyceride levels.

One danger of gene editing is the process may result in modification of DNA that scientists are not expecting. “You will never be able to have no off-target effects,” warned Dr. Deepak Srivastava, president of the Gladstone Institutes in San Francisco.

In treating a condition as common as heart disease, he added, even an uncommon side effect can mean many patients are affected. So far, however, the researchers say that they have not seen any inadvertent editing of other genes.

Another question is how long the effect on cholesterol and triglyceride levels will last, Dr. Davidson said. “We hope it will be

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Prototype Vaccine Protects Monkeys From Coronavirus

A prototype vaccine has protected monkeys from the coronavirus, researchers reported on Wednesday, a finding that offers new hope for effective human vaccines.

Scientists are already testing coronavirus vaccines in people, but the initial trials are designed to determine safety, not how well a vaccine works. The research published Wednesday offers insight into what a vaccine must do to be effective and how to measure that.

“To me, this is convincing that a vaccine is possible,” said Dr. Nelson Michael, the director of the Center for Infectious Diseases Research at Walter Reed Army Institute of Research.

Scientists are engaged in a worldwide scramble to create a vaccine against the new coronavirus. Over a hundred research projects have been launched; early safety trials in humans have been started or completed in nine of them.

Next to come are larger trials to determine whether these candidate vaccines are not just safe, but

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